ARTICLES

ALL SYSTEMS GO. Jan Van der Greef
(Nature magazine)
Various cultures have developed their own philosophies of science and, consequently, practices in medicine. The twentieth century has seemed to vindicate the Western approach, bringing huge advances in our understanding of physiology and biochemistry. This knowledge has fuelled the development of medicines and vaccines against countless diseases that had once wreaked havoc on humanity...(Read more)

SUB-TYPING OF RHEUMATIC DISEASES BASED ON A SYSTEMS DIAGNOSIS QUESTIONNAIRE. Herman van Wietmarschen et. al
(Plosone)
The future of personalized medicine depends on advanced diagnostic tools to characterize responders and non-responders to treatment. Systems diagnosis is a new approach which aims to capture a large amount of symptom information from patients to characterize relevant sub-groups...(Read more)

MEASUREMENT OF INTERNAL BODY TIME BY BLOOD METABOLOMICS. Minami Y et. al
(NCBI)
Detection of internal body time (BT) via a few-time-point assay has been a longstanding challenge in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To address this challenge, we previously developed the concept, "molecular-timetable method," which was originally inspired by Linné's flower clock. In Linné's flower clock, one can estimate the time of the day by watching the opening and closing pattern of various flowers. Similarly, in the molecular-timetable method, one can measure the BT of the day by profiling the up and down patterns of substances in the molecular timetable...(Read more)